A Better Harvest
The regenerative qualities of bone marrow have been used for decades and are considered the gold standard for stem cell harvesting. However, after the first 1-2 mL of bone marrow aspirate from a traditional needle, the number of total nucleated cells (TNC) in the aspirate drops dramatically due to the lower viscosity of blood and the design of the needle, which operates most optimally for small biopsy volume. After aspirating the first 1-2 mL of bone marrow, peripheral blood will preferentially fill the vacated space, limiting the additional harvest of key stem and progenitor cells. The patented AutograftX™ Bone Harvesting System overcomes the limitations of a traditional trocar needle by allowing the user to capture high quality autograft and marrow aspirate in a measured and controlled manner over a large geography inside the marrow space, while restricting peripheral blood infiltration. The result is a combination harvest that includes graft material that is osteoconductive, osteoinductive, & osteogenic and an aspirate so rich in key stem and progenitor cells that it does not have to be manipulated through centrifugation prior to application.
Better Bone Marrow AspirateThe highest stem cell concentration and yield as compared to five other systems used for BMA, as shown by the data below. Surgeons can use the BMA from the AutograftX™ System to hydrate their choice of autograft or allograft.
Significant Cost SavingsNo centrifuge means less OR time, decreased risk of infection (by not breaking the sterile field), no inspection or storage costs and no need for additional disposables.
The AutograftX™ System maximizes stem and progenitor cell recovery and minimizes peripheral blood contamination. Thus, it prevents the subsequent need for additional manipulation procedures such as centrifugation and/or chemical separation which usually require oversight by national regulatory authorities. AutograftX™ harvests high quality percutaneous bone graft dowels in the same surgical procedure via the same access site, significantly reducing the need for more invasive harvesting procedures that burden the patient and health care provider with more expensive, time intensive, traumatic techniques that increase post-operative pain and morbidity, pharmacologic demand and length of hospitalization.
- Reduces Peripheral Blood Contamination
- Closed-end Aspiration Design
- Cannula via Sheath Technology
- Lateral vs. Distal Collection
- Never Leaves Sterile Field
- Higher CFU-f Counts per mL
- Autologous Bone Graft Collection
- Additional Steps Not Required
- Minimally invasive
- Low volume—High Yield & Quality
- Regulatory Compliant
- Single Puncture— Multiple Aspirations
INTACT BONE DOWELS VS. MORSELIZED BONE
Harvesting an intact cancelleous bone dowel which does not disrupt the highly-organized living tissue of the bone is different from transplanting pieces of bone. Such grafts that maintain the micro-vascular within the graft do not show extensive resorption, callus formation or remodeling. The inherent difference is based on the ability of intact bone to exploit the biology of normal fracture healing rather than through creeping substitution that is fundamental to the incorporation of a non-vascularized graft. Research demonstrates the enhanced survival of a free bone graft as long as its primary blood supply is preserved or re-constituted. A living bone graft will shorten the time for boney union because the reconstructed bone is comparable to a bone with a double fracture. Allogenic or synthetic bone chips hydrated with marrow can be packed around the living bone graft/dowel to accelerate anastomosis into the graft and minimize the amount of morbidity. Vascularized and cancellous autograft show optimal skeletal incorporation but are limited by morbidity concerns. Using the Marrow Cellution™ graft delivery syringe and the Marrow Cellution™ Bone Dowel Harvest device, the clinician can create a combination graft of a vascularized intact bone dowel in the center of the graft surrounded by allogeneic, autologous or synthetic bone chips hydrated with high cellular marrow aspirate. Higher quality, less quantity, delivered appropriately minimizes host morbidity.
Intact Cancellous Bone Dowel
Minimally invasive technique, using 8 gauge trephine needle for bone dowel extraction
Graft material with osteoconductive, osteoinductive & osteogenic properties
May be combined with allogenic, autologous or synthetic bone chips hydrated with high cellular marrow aspirate.
"The AutograftX system represents a giant step in bone marrow harvesting. This system eliminates all the drawbacks from centrifuge based systems and produces a better biologic."Dr. Joseph Daniels, D.O.
"Hands down, the best method is the new Marrow Cellution needle. It’s a game changer."Paul D. Tortland, D.O.
All Kits Include
11 Gauge x 3.5" Introducer NeedleBeveled point stylet permits easy penetration into the specimen with less trauma to surrounding tissues and organs.
11 Gauge Blunt StyletUsed for further advancement within the marrow space without causing additional trauma to minimize peripheral blood infiltration.
14 Gauge Aspiration CannulaClosed tip cannula with distal openings to prevent peripheral blood infiltration and threaded guide for controlled movement.
10 mL SyringeSterile leur lock piston syringe. 10ml for increased negative pressure over larger volume syringes.
Snarecoil Bone Extraction ToolPatented mechanism retains and locks autograft sample inside needle lumen.
11 Gauge x 3.5" Introducer Needle
11 Gauge Blunt Stylet
14 Gauge Aspiration Cannula
10 mL Syringe
8 Gauge x 4" Swaged Tip Introducer Needle
Snarecoil Bone Extraction Tool
Cancellous Crushed, 4 – 10 mm, 15 cc